Information Sheet 6: Selenium
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چکیده
In the 1996 Nutritional Prevention of Cancer (NPC) trial, selenium supplementation was associated with a reduced risk of prostate cancer. This relationship was further studied in two large well‐ designed clinical trials, but no significant associations were found. However, the study populations in both of these trials had a moderate to high selenium status while the NPC trial population had a low selenium status [3]. It is now suggested that selenium supplementation may protect against cancer in populations with a low selenium status.
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Structural characterization of selenium and selenium-diiodine analogues of the antithyroid drug 6-n-propyl-2-thiouracil and its alkyl derivatives.
The structures of four selenium analogues of the antithyroid drug 6-n-propyl-2-thiouracil [systematic name: 2,3-dihydro-6-n-propyl-2-thioxopyrimidin-4(1H)-one], namely 6-methyl-2-selenouracil, C(5)H(6)N(2)OSe (1), 6-ethyl-2-selenouracil, C(6)H(8)N(2)OSe (2), 6-n-propyl-2-selenouracil, C(7)H(10)N(2)OSe (3), and 6-isopropyl-2-selenouracil, C(7)H(10)N(2)OSe (4), are described, along with that of t...
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Selenium is an important nutrient. The lack of selenium will suppress expression of various enzymes that will lead to cell abnormality and diseases. However, high concentrations of free selenium are toxic to the cell because it adversely affects numerous cell metabolic pathways. In Methanococcus vannielii, selenium transport in the cell is established by the selenium-binding protein, SeBP. SeBP...
متن کاملProspective observation of breast/ovarian cancer risk in BRCA1 carriers depending on serum selenium level optimized with diet
The aim of the study is to observe prospectively the possibility of lowering the cancer risk among BRCA1 carriers by optimizing selenium concentration in diet/ organism. Results of studies performed in several centres, particularly of our own search, are strongly indicating on potential of decreasing breast/ovarian cancer risk among carriers by optimization of selenium concentration in the body...
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This article presents a seven-step procedure for developing environmentally safe total maximum daily loads (TMDLs) for selenium. The need for this information stems from recent actions taken by the U.S. Environmental Protection Agency (EPA) that may require TMDLs for selenium and other contaminants that are impairing water bodies. However, there is no technical guidance from EPA or elsewhere th...
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Background: Micronutrient deficiencies of zinc and selenium can lead to thyroid dysfunction. The objective of this study was to determine the effects of zinc and selenium supplementation on thyroid function of over-weight or obese hypothyroid female patients. Methods : This was a double-blind randomized clinical trial study. Sixty-eight over-weight or obese hypothyroid female patients rando...
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